Abstract: Lysosomes are the main degradative organelles in eukaryotic cells, and their dysfunction is closely related to many diseases.The current knowledge on the connection between lysosomal dysfunction and neurodegenerative diseases were reviewed with the focus on lysosomal enzymes, pH regulation, lysosomal membrane proteins, and intracellular localization of lysosomes. It provided a new perspective for understanding the mechanism of neurodegenerative diseases, and also looke

Key words: lysosome, neurodegenerative disease, lysosomal storage disease, lysosomal enzyme, lysosomal membrane protein